A co-authored article has been published

Our collaborator, Prof. Sando, and his lab members have published an article. Ueki R, Atsuta S, Ueki A, Hoshiyama J, Li J, Hayashi Y, Sando S. DNA aptamer assemblies as fibroblast growth factor mimics and their application in stem cell culture. Chem Commun (Camb). 2019 Feb 26;55(18):2672-2675. doi: 10.1039/c8cc08080a. PubMed PMID: 30746545. They developed DNA aptamer-assemblies that act as functional mimics of basic fibroblast growth factor (bFGF), one of the essential factors for stem cell culture. The most potent aptamer assembly named TD0, composed solely of 76-mer single-stranded DNA, could support the self-renewal and pluripotency of induced pluripotent stem cells (iPSCs). This work presents the first application of DNA aptamer in Continue reading A co-authored article has been published

A co-authored article has been published

A co-authored article has been published with my former lab, the gene regulation lab at University of Tsukuba. Live-cell imaging of subcellular structures for quantitative evaluation of pluripotent stem cells Ken Nishimura, Hiroshi Ishiwata, Yuta Sakuragi, Yohei Hayashi, Aya Fukuda & Koji Hisatake Scientific Reports volume 9, Article number: 1777 (2019)  

Our article has been selected as an editors’ picks

Our article, “Automated adherent cell elimination by a high-speed laser mediated by a light-responsive polymer”, has been selected as an editors’ pick in Communications Biology first year anniversary collection. I’m very happy that the article is highly evaluated.

Call for applications for the position of Special Postdoctoral Researcher (SPDR) for FY 2020

RIKEN is currently accepting applications for the FY 2020 Special Postdoctoral Researcher (SPDR) Program, from young, creative, independent researchers who will be a powerful force in furthering RIKEN’s research activities. Our lab has joined this program as a host lab. So far, no candidates are assigned. Please let us know if you are eligible and interested. http://www.riken.jp/en/careers/programs/spdr/career2020/

A new research article has been published

We have published a new research article in Communications Biology, a newly launched journal from Springer Nature. We have developed a system of automated adherent cell elimination by a high-speed laser mediated by a light-responsive polymer, called LiLACK (Laser-induced, Light-responsive- polymer-Activated, Cell Killing). We have demonstrated that human induced pluripotent stem cells (hiPSCs) maintained their pluripotency and self-renewal during long-term culture using this system in each passage for sectioning. Furthermore, combined with deep machine-learning analysis on fluorescent and phase contrast images, we have developed a label-free and automatic cell processing system by eliminating unwanted spontaneously differentiated cells in undifferentiated hiPSC culture conditions.     Full article can be read below the Continue reading A new research article has been published

Invited lecture at Joint Japan-Spain Symposium on Medical Research

On November 7, Yohei Hayashi gave an invited lecture at Joint Japan-Spain Symposium on Medical Research. This symposium was held in celebrating the 150th Anniversary of Japan-Spain diplomatic relations and was sponsored by Japan AMED (Agency for Medical Research and Development) and Ministry of Science, Innovation and Universities in Spain with the support of the embassy of Japan in Madrid.