A research article on structurally-discovered KLF4 variants accelerate and stabilize reprogramming to pluripotency
We discovered KLF4 variants which accelerate and stabilize reprogramming to pluripotency. Borisova E, Nishimura K, An Y, Takami M, Li J, Song D, Matsuo-Takasaki M, Luijkx D, Aizawa S, Kuno A, Sugihara E, Sato T, Yumoto F, Terada T, Hisatake K, Hayashi Y. Structurally-discovered KLF4 variants accelerate and stabilize reprogramming to pluripotency. iScience. 2021 Dec 21:103525. doi.org/10.1016/j.isci.2021.103525 Our study demonstrates how modifications in amino acid residues of DNA-binding domains enable next-generation reprogramming technology with engineered reprogramming factors.