We have published a review article about “Studying Abnormal Chromosomal Diseases Using Patient-Derived Induced Pluripotent Stem Cells” in Frontiers in Cellular Neuroscience. Hayashi Y, Takami M, Matsuo-Takasaki M. Studying Abnormal Chromosomal Diseases Using Patient-Derived Induced Pluripotent Stem Cells. Front Cell Neurosci. 2020;14:224. Published 2020 Aug 13. doi:10.3389/fncel.2020.00224

Two new undergraduate student trainees has been joined from the pharmaceutical department of Tokyo University of Science. Let’s do the best science together!

We have published a research article on the generation and characterization of iPS cells from patient cells of genetic kidney disease. Arai Y, Takami M, An Y, Matsuo-Takasaki M, Hemmi Y, Wakabayashi T, Inoue J, Noguchi M, Nakamura Y, Sugimoto K, Takemura T, Okita K, Osafune K, Takasato M, Hayata T, Hayashi Y.Generation of two human induced pluripotent stem cell lines derived from two juvenile nephronophthisis patients with NPHP1 deletion.Stem Cell Res. 2020 May;45:101815. doi: 10.1016/j.scr.2020.101815. Epub 2020 Apr 21. PMID: 32361464 I’d like to thank all the co-authors.Congratulations, Arai-kun! We’re aiming to use these iPS cells to develop disease models and new therapies of nephronophthisis !

RIKEN’s International Program Associate (IPA) is a non-Japanese doctoral candidate attending a Japanese or overseas graduate school participating in RIKEN’s joint graduate school program. IPAs conduct research at RIKEN under the supervision of RIKEN scientists as part of work toward obtaining a PhD. RIKEN’s joint graduate school program is based on agreements with a number of Japanese and overseas universities and aims to identify and foster talented young scientists capable of contributing to the advancement of science for the global community.https://www.riken.jp/en/careers/programs/ipa/index.html Now, we’re recruiting IPA during this October to next March.The deadline is April 30. If you’re eligible and interested in our lab,please let me know by an email.

By the end of March, we had 4 lab members left our lab. One undergraduate trainee goes on to public graduate school in Tokyo.Two master program trainees join a Japanese big cosmetic company and an international pharmaceutical company.One technical staff joins our collaborative startup company in Tokyo. I really congratulate them and wish for their future success.

Now, RIKEN is calling for applications for the position of Special Postdoctoral Researcher (SPDR) for FY 2021.https://www.riken.jp/en/careers/programs/spdr/career2021/index.html Also, we can employ one junior postdoc (within around 5 years after getting PhD) in my laboratory now. Please let me know if you’re interested to study using human iPS cells in Tsukuba, Japan!

A new co-authored article has been published in Cell Reports.This study reveals the molecular mechanisms of retroviral silencing associated with pluripotency and reprogramming and is mainly done by Gene regulation Lab in University of Tsukuba (my former lab).Congratulations, Phuon Linh, Nishimura-sensei, and Hisatake-sensei! Bui PL, Nishimura K, Seminario Mondejar G, Kumar A, Aizawa S, Murano K, Nagata K, Hayashi Y, Fukuda A, Onuma Y, Ito Y, Nakanishi M, Hisatake K. Template Activating Factor-I α Regulates Retroviral Silencing during Reprogramming. Cell Rep. 2019 Nov 12;29(7):1909-1922.e5. doi: 10.1016/j.celrep.2019.10.010. PubMed PMID: 31722206.

A new co-authored article has been published in PLos One.This study establishes the knock-in mice in UCP1 locus to illuminate the brown and beige fat tissues in living animals and mainly done by gene regulation laboratory (my former lab) in University of Tsukuba.Congratulations, Fukuda-sensei, Honda-san, and Hisatake-sensei! Fukuda A, Honda S, Fujioka N, Sekiguchi Y, Mizuno S, Miwa Y, Sugiyama F, Hayashi Y, Nishimura K, Hisatake K. Non-invasive in vivo imaging of UCP1 expression in live mice via near-infrared fluorescent protein iRFP720. PLoS One. 2019 Nov 15;14(11):e0225213. doi: 10.1371/journal.pone.0225213. eCollection 2019. PubMed PMID: 31730675.

An intern student, Dorian Luijkx, in the Master Course of Utrecht University, has joined our team. He will stay and do experiments until next July in our lab. Good luck and have fun with us!

RIKEN Junior Research Associate program is now open. This program is to give salary for PhD students who are working in RIKEN laboratory and are enrolled in PhD course in Japanese University. This time is for those starting from April or October next year. If you are eligible and interested in our laboratory research, please email me. Since the application deadline is November 8th, please contact me as soon as possible. (Although if you contact me, please understand that I cannot promise that you can apply. Also, although if you are allowed to apply with my approval, I cannot promise that you can work in our laboratory unless the application Continue reading RIKEN Junior Research Associate Program Is Now Open→