2023
Nakade K, Tsukamoto S, Nakashima K, An Y, Sato I, Li J, Shimoda Y, Hemmi Y,
Miwa Y, Hayashi Y. Efficient selection of knocked-in pluripotent stem cells
using a dual cassette cellular elimination system. Cell Rep Methods. 2023 Dec
18;3(12):100662. doi: 10.1016/j.crmeth.2023.100662. Epub 2023 Dec 11. PMID:
38086384; PMCID: PMC10753384.
Takahi M, Taira R, Onozuka J, Sunamura H, Kondow A, Nakade K, Nakashima K,
Sato I, Hayashi Y, Patra C, Ohnuma K. Xenograft of human pluripotent stem cell-
derived cardiac lineage cells on zebrafish embryo heart. Biochem Biophys Res
Commun. 2023 Sep 24;674:190-198. doi: 10.1016/j.bbrc.2023.06.040. Epub 2023 Jun 14. PMID: 37532637.
2022
Song D, Takahashi G, Zheng YW, Matsuo-Takasaki M, Li J, Takami M, An Y, Hemmi
Y, Miharada N, Fujioka T, Noguchi M, Nakajima T, Saito MK, Nakamura Y, Oda T,
Miyaoka Y, Hayashi Y. Retinoids rescue ceruloplasmin secretion and alleviate
oxidative stress in Wilson’s disease-specific hepatocytes. Hum Mol Genet. 2022
Apr 7:ddac080. doi: 10.1093/hmg/ddac080. Epub ahead of print. PMID: 35388883.
Shimoda Y, Murakoshi N, Mori H, Xu D, Tajiri K, Hemmi Y, Sato I, Noguchi M,
Nakamura Y, Hayashi Y, Ieda M. Generation of a human induced pluripotent stem
cell line derived from a patient with dilated cardiomyopathy carrying LMNA
nonsense mutation. Stem Cell Res. 2022 Jul;62:102793. doi:
10.1016/j.scr.2022.102793. Epub 2022 Apr 27. PMID: 35500377.
Anh LPH, Nishimura K, Kuno A, Linh NT, Kato T, Ohtaka M, Nakanishi M,
Sugihara E, Sato TA, Hayashi Y, Fukuda A, Hisatake K. Downregulation of Odd-
Skipped Related 2, a Novel Regulator of Epithelial-Mesenchymal Transition,
Enables Efficient Somatic Cell Reprogramming. Stem Cells. 2022 Apr
29;40(4):397-410. doi: 10.1093/stmcls/sxac012. PMID: 35385105.
Shimizu T, Matsuo-Takasaki M, Luijkx D, Takami M, Arai Y, Noguchi M, Nakamura
Y, Hayata T, Saito MK, Hayashi Y. Generation of human induced pluripotent stem
cell lines derived from four DiGeorge syndrome patients with 22q11.2 deletion.
Stem Cell Res. 2022 May;61:102744. doi: 10.1016/j.scr.2022.102744. Epub 2022 Mar 9. PMID: 35292424.
Aizawa S, Nishimura K, Mondejar GS, Kumar A, Bui PL, Tran YTH, Kuno A,
Muratani M, Kobayashi S, Nabekura T, Shibuya A, Sugihara E, Sato TA, Fukuda A,
Hayashi Y, Hisatake K. Early reactivation of clustered genes on the inactive X
chromosome during somatic cell reprogramming. Stem Cell Reports. 2022 Jan
11;17(1):53-67. doi: 10.1016/j.stemcr.2021.11.008. Epub 2021 Dec 16. PMID:
34919813; PMCID: PMC8758948.
2021
Borisova E, Nishimura K, An Y, Takami M, Li J, Song D, Matsuo-Takasaki M, Luijkx D, Aizawa S, Kuno A, Sugihara E, Sato T, Yumoto F, Terada T, Hisatake K, Hayashi Y. Structurally-discovered KLF4 variants accelerate and stabilize reprogramming to pluripotency. iScience. 2021 Dec 21:103525. doi.org/10.1016/j.isci.2021.103525.
Ugawa M, Kawamura Y, Toda K, Teranishi K, Morita H, Adachi H, Tamoto R,
Nomaru H, Nakagawa K, Sugimoto K, Borisova E, An Y, Konishi Y, Tabata S,
Morishita S, Imai M, Takaku T, Araki M, Komatsu N, Hayashi Y, Sato I, Horisaki
R, Noji H, Ota S. In silico-labeled ghost cytometry. Elife. 2021 Dec
21;10:e67660. doi: 10.7554/eLife.67660. PMID: 34930522; PMCID: PMC8691837.
Song D, Zheng YW, Hemmi Y, An Y, Noguchi M, Nakamura Y, Oda T, Hayashi Y.
Generation of human induced pluripotent stem cell lines carrying homozygous JAG1
deletions. Stem Cell Res. 2021 Oct 26;57:102588. doi: 10.1016/j.scr.2021.102588.
Epub ahead of print. PMID: 34736037.
Tsukamoto S, Nakade K, Wakabayashi T, Nakashima K, Takami M, Hemmi Y, Kuramochi Y, Shimizu T, Arai Y, Matsuo-Takasaki M, Noguchi M, Nakamura Y, Miwa Y, Hayashi Y. Generation of two ISL1-tdTomato reporter human induced pluripotent stem cell lines using CRISPR-Cas9 genome editing. Stem Cell Res. 2021 May;53:102363. doi: 10.1016/j.scr.2021.102363. Epub 2021 Apr 22. PMID: 34087992.
Kuramochi Y, Awaya T, Matsuo-Takasaki M, Takami M, An Y, Li J, Hemmi Y, Wakabayashi T, Arai Y, Inoue J, Noguchi M, Nakamura Y, Asaka I, Akimoto K, Saito MK, Hayashi Y. Generation of two human induced pluripotent stem cell lines derived from two X-linked adrenoleukodystrophy patients with ABCD1 mutations. Stem Cell Res. 2021 May;53:102337. doi: 10.1016/j.scr.2021.102337. Epub 2021 Apr PMID: 33901816.
2020
Arai Y, Takami M, An Y, Matsuo-Takasaki M, Hemmi Y, Wakabayashi T, Inoue J, Noguchi M, Nakamura Y, Sugimoto K, Takemura T, Okita K, Osafune K, Takasato M, Hayata T, Hayashi Y.
Generation of two human induced pluripotent stem cell lines derived from two juvenile nephronophthisis patients with NPHP1 deletion.
Stem Cell Res. 2020 May;45:101815. doi: 10.1016/j.scr.2020.101815. Epub 2020 Apr 21. PMID: 32361464
2019
Bui PL, Nishimura K, Seminario Mondejar G, Kumar A, Aizawa S, Murano K, Nagata K, Hayashi Y, Fukuda A, Onuma Y, Ito Y, Nakanishi M, Hisatake K. Template Activating Factor-I α Regulates Retroviral Silencing during Reprogramming. Cell Rep. 2019 Nov 12;29(7):1909-1922.e5. doi: 10.1016/j.celrep.2019.10.010. PubMed
PMID: 31722206.
Fukuda A, Honda S, Fujioka N, Sekiguchi Y, Mizuno S, Miwa Y, Sugiyama F, Hayashi Y, Nishimura K, Hisatake K. Non-invasive in vivo imaging of UCP1 expression in live mice via near-infrared fluorescent protein iRFP720. PLoS One. 2019 Nov 15;14(11):e0225213. doi: 10.1371/journal.pone.0225213. eCollection 2019. PubMed PMID: 31730675.
Ueki R, Atsuta S, Ueki A, Hoshiyama J, Li J, Hayashi Y, Sando S. DNA aptamer assemblies as fibroblast growth factor mimics and their application in stem cell culture. Chem Commun (Camb). 2019 Feb 26;55(18):2672-2675. doi: 10.1039/c8cc08080a. PubMed PMID: 30746545.
Nishimura K, Ishiwata H, Sakuragi Y, Hayashi Y, Fukuda A, Hisatake K. Live-cell imaging of subcellular structures for quantitative evaluation of pluripotent stem cells. Sci Rep. 2019 Feb 11;9(1):1777. doi: 10.1038/s41598-018-37779-x. PubMed PMID: 30741960; PubMed Central PMCID: PMC6370783.
2018
- Yohei Hayashi+, Junichi Matsumoto, Shohei Kumagai, Kana Morishita, Long Xiang, Yohei Kobori, Seiji Hori, Masami Suzuki, Toshiyuki Kanamori, Kazuhiro Hotta+ & Kimio Sumaru+ “Automated adherent cell elimination by a high-speed laser mediated by a light-responsive polymer” Commun Biol. 2018 Dec 7;1:218. doi: 10.1038/s42003-018-0222-4. eCollection 2018. PMID: 30534610
- Nakamura S, Maruyama A, Kondo Y, Kano A, De Sousa OM, Iwahashi M, Hexig B, Akaike T, Li J, Hayashi Y, Ohnuma K. “Asymmetricity Between Sister Cells of Pluripotent Stem Cells at the Onset of Differentiation.” Stem Cells Dev. 2018 Mar 1;27(5):347-354. doi: 10.1089/scd.2017.0113. Epub 2018 Feb 21. PMID: 29336219
- Tran THY, Fukuda A, Aizawa S, Bui PL, Hayashi Y, Nishimura K, Hisatake K. “Live cell imaging of X chromosome reactivation during somatic cell reprogramming.” Biochem Biophys Rep. 2018 Jul 24;15:86-92. doi: 10.1016/j.bbrep.2018.07.007. eCollection 2018 Sep. PMID: 30094351
2017
- Nishimura K, Aizawa S, Nugroho FL, Shiomitsu E, Yen HTT, Linh BP, Evgeniia BD, Sakuragi Y, Takada H, Kurisaki A, Hayashi Y, Fukuda Y, Nakanishi M, Hisatake K. “A role for KLF4 in promoting the metabolic shift via TCL1 during induced pluripotent stem cell generation.” Stem Cell Reports 8(3): 787-801, 2017
2016
- Hayashi Y+, Hsiao EC, Sami S, Lancero M, Schlieve CR, Nguyen T, Yano K, Nagahashi A, Ikeya M, Matsumoto Y, Nishimura K, Fukuda A, Hisatake K, Tomoda K, Asaka I, Toguchida J, Conklin BR, and Yamanaka S. “BMP-SMAD-ID Promotes Reprogramming to Pluripotency by Inhibiting p16/INK4A-Dependent Senescence.” Natl. Acad. Sci. USA113(46): 13057-62, 2016
- Kime C, Sakaki-Yumoto, Goodrich L, Hayashi Y, Sami S, Derynck R, Asahi M, Panning B, Yamanaka S, and Tomoda K: Autotaxin-mediated Lipid Signaling Intersects with LIF and BMP Signaling to Promote the Naïve Pluripotency Transcription Factor Program. Natl. Acad. Sci. USA 113(44): 12478-83, 2016
2015
- Hayashi Y*, Caboni L*, Das D, Yumoto F, Clayton T, Deller MC, Nguyen P, Farr CL, Chiu HJ, Miller M, Elsliger MA, Deacon AM, Godzik A, Lesley SA, Tomoda K, Conklin BR, Wilson IA, Yamanaka S, Fletterick, RJ. “Structure-based discovery of NANOG variant with enhanced properties to promote self-renewal and reprogramming of pluripotent stem cells” Proc Natl Acad Sci U S A 112(15): 4666-71, 2015.
2014
- Bershteyn M*, Hayashi Y*, Desachy G, Hsiao EC, Sami S, Tsang KMJ, Weiss LA, Kriegstein AR, Yamanaka S, Wynshaw-Boris A. “Cell-Autonomous Correction of Ring Chromosomes in Human Induced Pluripotent Stem Cells.” Nature 507(7490): 99-103, 2014.
- Spencer IC, Baba S, Nakamura K, Hua EA, Sears MAF, Fu C, Zhang J, Balijepalli S, Tomoda K, Hayashi Y, Lizarraga P, Wojciak J, Scheinman MM, Aalto-Setälä K, Jonathan C, Makielski JC, January CT, Healy KE, Kamp TJ, Yamanaka S, Conklin BR. “Ca2+ Transients Closely Reflect Prolonged Action Potentials in iPS Cell Models of Inherited Cardiac Arrhythmia.” Stem Cell Reports 3(2): 269-81, 2014.
- Ohnuma K, Fujiki A, Yanagihara K, Tachikawa S, Hayashi Y, Ito Y, Onuma Y, Chan T, Michiue T, Furue MK, Asashima M. “Enzyme-free Passage of Human Pluripotent Stem Cells by Controlling Divalent Cations.” Sci Rep 4: 4646, 2014.
- Worringer KA, Rand TA, Hayashi Y, Sami S, Takahashi K, Tanabe K, Narita M, Srivastava D, Yamanaka S. “The let-7 Target LIN-41 Promotes Induced Pluripotent Stem Cell Reprogramming.” Cell Stem Cell 14(1): 40-52, 2014.
2013
- Matsumoto Y*, Hayashi Y*, Schlieve CR*, Kim H, Nguyen TD, Nakamura K, Collins W, Ivey K, Baba S, Sami S, Otsuka T, Asaka I, Nasu A, Yokoyama K, Srivastava D, Yamanaka S, Ikeya M, Toguchida J, Conklin BR, Hsiao EC. “Induced pluripotent stem cells from patients with human fibrodysplasia ossificans progressiva show increased mineralization and cartilage formation.” Orphanet J Rare Dis 8:190, 2013.
- Fu JD, Stone NR, Liu L, Spencer IC, Qian L, Hayashi Y, Delgado-Olguin P, Ding S, Bruneau BG, Srivastava D. “Direct Reprogramming of Human Fibroblasts toward the Cardiomyocyte Lineages.” Stem Cell Reports 1(3): 235-47, 2013.
- Oeda S, Hayashi Y, Chan T, Takasato M, Aihara Y, Okabayashi K, Ohnuma K, Asashima M. “Induction of Intermediate Mesoderm by Retinoic Acid Receptor Signaling from Differentiating Mouse Embryonic Stem Cells.” Int J Dev Biol 57(5): 383-9, 2013.
2010
- Ieda M, Fu JD, Delgado-Olguin P, Vedantham V, Hayashi Y, Bruneau BG, Srivastava, D. “Direct reprogramming of fibroblasts into functional cardiomyocytes by defined factors.” Cell 142(3): 375-86, 2010.
- Hayashi Y*, Chan T*, Warashina M, Fukuda M, Ariizumi T, Okabayashi K, Takayama N, Otsu M, Eto K, Furue MK, Michiue T, Ohnuma K, Nakauchi H, Asashima M. “Reduction of N-Glycolylneuraminic Acid in Human Induced Pluripotent Stem Cells Generated or Cultured under Feeder- and Serum-Free Defined Conditions.” PLoS One 5(11): e14099, 2010.
- Aihara Y, Hayashi Y, Hirata M, Ariki N, Shibata S, Nagoshi N, Nakanishi M, Ohnuma K, Warashina M, Michiue T, Uchiyama H, Okano H, Asashima M, Furue MK. “Induction of neural crest cells from mouse embryonic stem cells in a serum-free monolayer culture.” Int J Dev Biol 54(8-9): 1287-94, 2010.
- Aoki R, Inui M, Hayashi Y, Sedohara A, Okabayashi K, Ohnuma K, Murata M, Asashima M. “An in vitro reconstitution system for the assessment of chromatin protein fluidity during Xenopus development.” Biochem Biophys Res Commun 400(2): 200-6, 2010.
2009
- Hayashi Y, Furue MK, Tanaka S, Hirose M, Wakisaka N, Danno H, Ohnuma K, Oeda S, Aihara Y, Shiota K, Ogura A, Ishiura S, Asashima M. “BMP4 induction of trophoblast from mouse embryonic stem cells in defined culture conditions on laminin.” In Vitro Cell Dev Biol Anim 46(5): 416-30, 2009.
- Nakanishi M, Kurisaki A, Hayashi Y, Warashina M, Ishiura S, Furue MK, Asashima M. “Directed induction of anterior and posterior primitive streak by Wnt from embryonic stem cells cultured in a chemically defined serum-free medium.” FASEB J 23(1): 114-22, 2009.
2007
- Hayashi Y, Furue M, Okamoto T, Ohnuma K, Myoishi Y, Fukuhara Y, Abe T, Sato JD, Hata RI, Asashima M. “Integrin regulates mouse embryonic stem cell self-renewal.” Stem Cells 25(12): 3005-15, 2007.
2006
2005
- Furue M, Okamoto T, Hayashi Y, Okochi H, Fujimoto M, Myoishi Y, Abe T, Ohnuma K, Sato GH, Asashima M, Sato JD. “Leukemia inhibitory factor as an anti-apoptic mitogen for pluripotent mouse ES cells in a serum-free medium without feeder cells.” In Vitro Cell Dev Biol Anim 41(1-2): 19-28, 2005.